Rice bran series

Summary

In the 1890s, a Dutch military physician, Christiaan Eijkman and his assistant discovered that polished “white rice” could cause leg weakness on chickens. It was later proved that the Vitamin B1 removed during the polishing (i.e. the rice bran) was the cause of sick chickens[1]. Subsequently, the micronutrients rich in rice bran were continuously discovered, such as oryzanol, sitosterol, vitamin E, squalene, etc.[2]

Since its establishment in 1994, Delekang has been dedicated to research and manufacture of rice bran series products. We have successively developed oryzanol, ferulic acid, rice bran sterol and phytosterol, continuously exploiting the value of rice bran.

History of rice bran series

  • In July 1995, gamma oryzanol was launched in the market.

  • In 2003, Delekang developed the rice bran oil of first-class in national standard.

  • In 2005, ferulic acid was introduced.

Rice bran oil

Introduction

In the perspective of nutrition, oils and fats is the carrier of fat-soluble Vitamin A, D and E, and also an important part of cell walls and other biological structures. In cooking, oils and fats also affect the flavor of food. [3]

Vitamin E, including our tocopherols and four tocotrienols [4], is a fat-soluble antioxidant that protects cell membrane from reactive oxygen species (ROS). [5]

Compared with tocopherols, tocotrienols have stronger anti-oxidant property[6], which are naturally derived from plant oil, especially rice bran oil.[7]

The content of Vitamin E in plant oils(mg/kg)[7]

Specification

Based on the national standard GB/T 19112-2003

Items Class 1 Class 2 Class 3
Color Lovibond 5 1/4″ Y ≤ 35 R ≤ 3.5 Y ≤ 35 R ≤ 5.0 --
Color Lovibond 1″ -- -- Y ≤ 35 R ≤ 3.0
Acid value (mg KOH/g) ≤ 0.20 ≤ 0.30 ≤ 1.0
Peroxide value (mmol/kg) ≤ 5.0 ≤ 5.0 ≤ 7.5
Solvent residue (mg/kg) ND ND ≤ 20
Soap content (%) -- -- ≤ 0.03
Insoluble impurities (%) ≤ 0.05 ≤ 0.05 ≤ 0.05
Moisture and volatiles (%) ≤ 0.05 ≤ 0.05 ≤ 0.10
Smoke point (°C) ≥ 215 ≥ 205 --
Refrigeration test (0°C) clear and transparent in 24h clear and transparent in 5.5h --
Iodine value (g/100g) 92-115 92-115 92-115

Packaging

Storage

Store in light-tight, airtight and dry condition

Gamma Oryzanol

CAS number: 11042-64-1

HS code: 29189900.90

National standard code: WS1-47(B)-89-2016

Introduction

Gamma oryzanol is a lipid composite mainly derived from rice bran. It is used to improve climacteric syndrome, anxiety, insomnia in Japan,[8] while in China, it is used for dysautonomia premenstrual syndrome and climacteric syndrome. [9]

Structure

24-Methylene cycloartanyl ferulate

24-Methylene cycloartanyl ferulate(35-40%)

 Cycloartenyl Ferulate

Cycloartenyl Ferulate(25-30%)

Campesteryl ferulate

Campesteryl ferulate (10-15%)

β-sitosteryl ferulate

β-sitosteryl ferulate (5-10%)

Specification

Items Standard
Assay 97.0 ~ 103.0%
Loss on drying ≤ 0.8%
Residue on ignition ≤ 0.2%
Heavy metal ≤ 10 mg/kg
Arsenic ≤ 2 mg/kg
Solubility Soluble in acetone, slightly soluble in orthane, insoluble in water

Packaging

20 kg/drum

Storage

Store in light-tight, airtight and dry condition

Ferulic acid

CAS number: 537-98-4

HS code: 29189900.90

Other name: (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid

Chemical formula C10H10O4

Molecular mass 194.184

Introduction

Ferulic acid is a very common component in natural plants and usually used as a raw material for spices. It mainly exists in the cell wall. Its tronger antioxidant property can protect cell, which make ferulic acid applicable as antioxidant and photostage inhabitation in cosmetics [10]. Ferulic acid also presents in some herbal medicines, such as female ginseng, Cimicifuga foetida and Ligusticum wallichii. [11]

Structure

阿魏酸

Specification

Items Standard
Content ≥ 99.0%
Loss on drying ≤ 0.5%
Residue on ignition ≤ 0.2%
Heavy metal ≤ 10 mg/kg
Arsenic ≤ 2 mg/kg
Melting point 170.0~174.0°C

Packaging

20 kg/drum

Storage

Store in light-tight, airtight and dry condition

Phytosterol

CAS number: 83-46-5

HS number: 29061990.90

Introduction

Sterols are the major trace substance in fat.

Cholesterol is a type of sterols, the main sterols in animal’s fat. There are two types of sterols in human blood: high-density lipoprotein (HDL)cholesterol and low-density lipoprotein (LDL) cholesterol. Excessive accumulation of LDL cholesterol in the serum can lead to blockage of arteries and heart disease.

Acceding to the EFSA

Moderate intake of phytosterol can lower blood cholesterol level and reduce the risk of coronary heart disease. [12]

The U.S. Food and Drug Administration (FDA) allows food labels to be noted:

Phytosterol can reduce the risk of coronary heart disease. [13]

Health Canada also allows it to be shown on food labels that plant sterol can help reduce cholesterol level. [14]

Although phytosterol has good stability, it can cause oxidation when it is exposed to high temperatures or the air. Eating oxidizing phytosterols can lead to inflammation, unstable hormone levels, carcinogenicity and other health problems.

Application

Industrial grade: it can be used as the starting material for steroid drugs

Food grade: it can be used as food additives, health care raw materials

Specification

Specification

Items 90/50 Size 95/50 Size
Total sterol ≥90.0% ≥95.0%
β-sitosterol ≥50.0% ≥50.0%
Stigmasterol / /
Campesterol / /
Residue on ignition ≤0.5% ≤0.5%
Loss on drying ≤2.0% ≤2.0%
Heavy metal ≤10mg/kg ≤10mg/kg
Arsenic ≤2mg/kg ≤2mg/kg
Solubility Soluble in thermal ethanol, slightly soluble in ethanol, insoluble in water. Soluble in thermal ethanol, slightly soluble in ethanol, insoluble in water.

Packaging

20 kg/drum

Storage

Store in airtight, light-tight and dry condition

Rice bran sterol

CAS number: 83-46-5

HS custom number: 2906199090

National standard code: WS-10001-(HD-0908)-2002

Introduction

Sterol, also known as Rice Bran Sterol Tablets in China, is used for bleeding gums, periodontal abscesses and other conditions caused by periodontal disease.

Specification

Items specification
Total sterol ≥63.0%
unsaponifiable matter ≥90.0%
Saponification ≤6.5mg KOH/g
Acid value ≤5.0mg KOH/g
Drying on loss ≤2.0%
The total number of aerobic bacteria ≤1000 cfu/g
The total number of molds and yeasts ≤100 cfu/g
E. coli Negative

Packaging

25 kg/drum

Storage condition

Prevented from light and stored in airtight and dry condition

Reference

  1. "The Nobel Prize and the Discovery of Vitamins". www.nobelprize.org.
  2. Barron, Jon (21 September 2010). "Black Rice Bran, the Next Superfood?". Baseline of Health Foundation.
  3. S. M. Ghazani; A. G. Marangoni (4 January 2016). "Healthy Fats and Oils". Encyclopedia of Food Grains, Vol: 2-4, 257-267.
  4. "Vitamin E". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. 1 October 2015.
  5. "Vitamin E". Office of Dietary Supplements, US National Institutes of Health. 12 July 2019.
  6. Serbinova E, Kagan V, Han D, Packer L (1991). "Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol". Free Radical Biology & Medicine. 10 (5): 263–75.
  7. 吴轲, 孙涵潇,祝 捷,蔡美琴.中国油脂[J].常见食用植物油中维生素 E 异构体含量调查研究,2019,(44-10):95-99.
  8. Fuji M, Butler JP, et al. Gamma-oryzanol for behavioural and psychological symptoms of dementia. Psychogeriatrics. 2018;18(2):151-152.
  9. 中华人民共和国卫生部药典委员会.中华人民共和国卫生部药品标准化学药品及制剂[M].谷维素, 1989,(1):H1-55.
  10. Zduńska K, Dana A, Kolodziejczak A, Rotsztejn H: Antioxidant Properties of Ferulic Acid and Its Possible Application. Skin Pharmacol Physiol 2018;31:332-336.
  11. Sakai, S.; Kawamata, H.; Kogure, T.; Mantani, N.; Terasawa, K.; Umatake, M.; Ochiai, H. (1999). "Inhibitory effect of ferulic acid and isoferulic acid on the production of macrophage inflammatory protein-2 in response to respiratory syncytial virus infection in RAW264.7 cells". Mediators of Inflammation. 8(3): 173–175.
  12. European Food Safety Authority. Scientific Opinion of the Panel on Dietetic Products Nutrition and Allergies on a request from Unilever PLC/NV on Plant Sterols and lower/reduced blood cholesterol, reduced the risk of (coronary) heart disease. The EFSA Journal (2008) 781, 1–12.
  13. U.S. Food & Drug Administration. Health claims: plant sterol/stanol esters and risk of coronary heart disease (CHD). 21 C.F.R. §101.83 (2017, April 1).
  14. Health Canada. (2010, May 26). Plant Sterols and Blood Cholesterol Lowering.

Ginkgo series

Ginkgo, native to China, is one of the oldest trees species in the world. It can date back to Carboniferous period (230,000 years ago). The average lifespan of ginkgo is between 2000 and 4000 years and its vitality is very tenacious.

As a traditional Chinese medical material, ginkgo has been cultivated and used for thousands of years.

  • In 2011, the first workshop of ginkgo biloba extract was put into trial production. In such a chaotic industry back then, we have always insisted on manufacturing authentic products.

  • In 2015, the former CFDA (China Food and Drug Administration, now the National Medical Products Administration) conducted an investigation on 90 Ginkgo biloba extract manufacturers across the country. Delekang is one of the few companies whose products were all certified as qualified. Our persistency in quality has been rewarded and we have gained a firm foothold in the market.

  • In 2016,Delekang’s ginkgo biloba extract was approved as API (Active Pharmaceutical Ingredient) by the former Jiangsu FDA. In the subsequent cooperation with various drug companies, we have been continuously optimizing the quality of ginkgo biloba extract to be able to consist stably in various dosage forms.

  • By 2019, we pushed the quality to a whole new level. Ginkgolic acid was controlled below 1ppm, and ginkgo toxin below 50 ppm. Pesticide residues met the EU regulation on maximum pesticide residue levels (EC No 396/2005).

  • In 2019, shikimic acid was found during the process of ginkgo biloba extraction, which could greatly reduce the cost of shikimic acid in the market.

  • Mass production of shikimic acid was achieved in 2020.

The data tell everything. With technical progress during the last ten years, we have made high-quality products more affordable for more people.

Ginkgo biloba extract

CAS number:90045-36-6

HS code:13021940.00

Summary

In the 1960s, Dr Willmar Schwabe Group developed standardized Ginkgo biloba extract EGb 761, which promotes vasodilation and improves blood flow through and is used to treat memory loss, tinnitus etc. [1]. In the assessment report of Ginkgo biloba in 2014, the European Medicines Agency recognized the therapeutic effect of Ginkgo biloba extract on the improvement of (age-associated) cognitive impairment and of quality of life in mild dementia[2]. In the United States, Ginkgo biloba extract is widely used as a dietary supplement [3]. In China, the main functions of ginkgo biloba extract preparations are:

Promoting blood circulation to remove obstruction in collaterals. It can be used for patients with chest blockage, heartache, stroke, hemiplegia, stiff tongue caused by blood stasis and obstruction of the collaterals, and stable angina pectoris and cerebral infarction with the syndromes mentioned above. [4] The Ginkgo biloba extract produced by Delekang has been approved by the Administration for Market Regulation (formerly Food and Drug Administration) and can be used as API (Active Pharmaceutical Ingredient) for the production of various drug preparations. At the same time, we have also obtained the "Food Production License", which permits us to produce Ginkgo biloba extract for dietary supplement.

Our advantages

Ginkgo biloba extract is a very common ingredient that almost every plant extract manufacturer can make. However, only few manufacturer can make ginkgo biloba extract of good quality, not to mention excellent quality. In the past decade, we have been constantly refreshing the quality level of ginkgo biloba extract:

  • Through years of cooperation with ginkgo leaf suppliers, we have been extensively collecting and analyzing the quality data of ginkgo leaves from different regions to find suitable raw materials for standardized products with stable quality.

  • Complying with Chinese Pharmacopoeia, U.S. Pharmacopoeia and European Pharmacopoeia standards

  • Complying with EU regulation on maximum pesticide residue levels (EC No 396/2005) .

  • Limiting ginkgolic acid below 1ppm

  • Limiting ginkgotoxin below 50ppm

  • The production line has been approved by China FDA

  • Compatible with most oral dosage forms

While ensuring high quality, Delekang is also striving to make products more affordable. Unlike plant extract manufacturers making everything, we have the following advantages as a specialized manufacturer:

  • Through technology development, the raw materials are fully utilized to reduce the cost of raw materials. The extracted ginkgo leaves and waste materials can be used to extract sodium copper chlorophyllin and shikimic acid, and the used leaves can be used as fuel to provide renewable energy for the production line.

  • Through scale effect, the fixed cost per unit, such as investment in R&D, equipment, and facilities, can be diluted through a larger output.

  • Unlike the universal extraction equipment, our specialized production line designed for ginkgo biloba is more effective in controlling quality and reducing cost of production.

Specifications

Items CP USP EP In-house
Flavonol glycosides ≥24.0% 22.0-27.0% 22.0-27.0% 22.0-27.0%
Terpene lactones ≥6.0% 5.4-12.0% 5.4-6.6% 5.4-12.0%
Bilobalide / 2.6-5.8% 2.6-3.2% 2.6-5.8%
Ginkgolide / 2.8-6.2% 2.8-3.4% 2.8-6.2%
Quercetin/kaempferol ratio 0.8-1.2 / / 0.8-1.2
Isorhamnetin/Quercetin ratio ≥0.15 / / ≥0.15
Ginkgolic acid ≤5mg/kg ≤5mg/kg ≤5mg/ kg ≤1mg/kg
Free quercetin ≤10mg/g ≤5mg/g / ≤10mg/g
Free kaempferol ≤10mg/g / / ≤10mg/g
Free isorhamnetin ≤4mg/g / / ≤4mg/g
Rutin / ≤4.0% / /
Pesticide residues / USP<561> EC396/2005 /
Loss on drying ≤5.0% ≤5.0% ≤5.0% ≤4.0%
Residue on ignition ≤0.8% / / ≤0.8%
Heavy metals ≤20m g/kg / / ≤15m g/kg
HPLC Fingerprint ≥0.90 / / ≥0.90

Package and storage

25 kg/drums; protected from light; stored in airtight and dry condition

Shikimic acid

CAS number: 138-59-0

HS Custom code: 2918190090

Structural formula

specification

Project specification Specific rotation 175 to -184 Content ≧98.0% Heavy metal ≦ 20 ppm Ash ≤ 0.8 % Loss on drying. ≤ 1.0% Solubility Easy to soluble in water (solubility: 18% m/v) Molecular weight 174.15 Character white or slightly yellow fine powder Plant source Ginkgo biloba

Packaging and storage

25kg/drum Prevented from light and stored in airtight and dry condition 参考文献 Reference 1. EGb 761: ginkgo biloba extract, Ginkor. Drugs R D. 2003;4(3):188-93. doi: 10.2165/00126839-200304030-00009. PMID: 12757407. 2. Committee on Herbal Medicinal Products. "Assessment report on Ginkgo biloba L., folium" (PDF). European Medicines Agency. 3. Z. Pang, F. Pan, and S. He.The Journal of Alternative and Complementary Medicine.Sep 1996.359-363. 4. 国家药典委员会.中华人民共和国药典[M].银杏叶片, 2020,(1):1614.

Green Tea series

Tea polyphenols

CAS number: 84650-60-2

HS customs number:

Appearance

Tea polyphenols, freely soluble in water, ethanol, ethyl acetate and slightly soluble in oils, are white to brown powdery solids or crystals with astringent taste. They are stable under hot or acidic condition in the range of PH 2~7. They are slightly hygroscopic, the PH of their aqueous solution is 3~4. Tea polyphenols are easy to be oxidized and become brown under alkaline condition. Green-black compounds are formed when they meet iron ions.

Specification

Specifications 98/80/50 98/75/45 50/30/15
Total polyphenols ≥98.0% ≥98.0% ≥50.0%
Catechins ≥80.0% ≥75.0% ≥30.0%
EGCG ≥50.0% ≥45.0% ≥15.0%
Caffeine ≤0.5% ≤1.0% ≤10.0%
Loss on drying ≤5.0% ≤5.0% ≤5.0%
Residue on ignition ≤3.0% ≤3.0% ≤3.0%
Heavy metals ≤10.0 mg/kg ≤10.0 mg/kg ≤10.0 mg/kg
Lead ≤5.0 mg/kg ≤5.0 mg/kg ≤5.0 mg/kg
Arsenic ≤2.0 mg/kg ≤2.0 mg/kg ≤2.0 mg/kg

Packaging

25kg/drum

Storage condition

Store in dark, airtight and dry place.

Theanine

CAS number: 3081-61-6

HS customs number:

Structural formula

 Theanine structure

Quality specification

Specification TP20 TP30 TP40 TP90
Appearance light yellow to light brown or dark brown powder white or almost white powder
Loss on drying ≤6.0%
Heavy metal ≤10mg/kg
Lead ≤2mg/kg
Arsenic ≤2mg/kg
Theanine ≥20.0% ≥30.0% ≥40.0% ≥90.0%
Total aerobic bacteria(cfu/g) ≤1000
Total molds and yeasts(cfu/g) ≤100
Escherichia Coli(1g) negative

Package

20kg/drum

Storage condition

prevented from light and stored in airtight and dry condition